Synthesis of New Hydrazones Containing 1,3-Diketo Moiety
Singh, Raman, Halve, Anand K. (2025). Synthesis of New Hydrazones Containing 1,3-Diketo Moiety. https://doi.org/10.70130/rcs.2025.0201001
Singh, Raman, Halve, Anand K.. "Synthesis of New Hydrazones Containing 1,3-Diketo Moiety.". DOI: 10.70130/rcs.2025.0201001.
Singh, Raman, Halve, Anand K.. "Synthesis of New Hydrazones Containing 1,3-Diketo Moiety.". https://doi.org/10.70130/rcs.2025.0201001.
@article{singh2025synthesis,
title = {Synthesis of New Hydrazones Containing 1,3-Diketo Moiety},
author = {Singh, Raman and Halve, Anand K.},
year = 2025,
journal = {},
volume = 02,
number = 01,
pages = 01-06,
doi = 10.70130/rcs.2025.0201001,
url = oai:ojs2.pubs.rsyn.org:article/96,
language = en
}
TY - JOUR TI - Synthesis of New Hydrazones Containing 1,3-Diketo Moiety AU - Singh, Raman AU - Halve, Anand K. PY - 2025 DA - 2025-06-28 VL - 02 IS - 01 SP - 01-06 DO - 10.70130/rcs.2025.0201001 UR - oai:ojs2.pubs.rsyn.org:article/96 AB - A series of novel hydrazones containing a 1,3-diketo moiety, namely 3-[(2E)-2-(4-hydroxybenzylidene)hydrazino]-3-oxo-N-phenylpropanamides (6a-j), were synthesized as precursors for biologically important β-lactam and thiazolidinone derivatives. The synthesis involved the condensation of 3-methoxy-4-hydroxybenzaldehyde or 3-methoxy-4-acetyloxybenzaldehyde with various substituted malonanilic acid hydrazides. The hydrazides (4a-e) were prepared by refluxing aniline with diethyl malonate, followed by treatment with hydrazine hydrate. The structures of the synthesized compounds were confirmed by elemental analysis and spectroscopic techniques, including IR, and 1H NMR spectrometry. The purity of the compounds was ascertained by thin-layer chromatography. The synthesized hydrazones (6a-j) were obtained in good yields (62-83%) and were soluble in dimethylformamide. The present study provides a foundation for further exploration of these 1,3-diketo amino compounds as promising scaffolds for developing novel heterocyclic compounds with diverse biological activities. LA - en ER -
🤖 AI Key Takeaways & Research Insights
Automated AI Analysis💡 Core Finding
A series of novel hydrazones containing a 1,3-diketo moiety, namely 3-[(2E)-2-(4-hydroxybenzylidene)hydrazino]-3-oxo-N-phenylpropanamides (6a-j), were synthesized as precursors for biologically important β-lactam and thi...
🔬 Methodology
The synthesis involved the condensation of 3-methoxy-4-hydroxybenzaldehyde or 3-methoxy-4-acetyloxybenzaldehyde with various substituted malonanilic acid hydrazides.
🎯 Domain Impact
The present study provides a foundation for further exploration of these 1,3-diketo amino compounds as promising scaffolds for developing novel heterocyclic compounds with diverse biological activitie...
Abstract
A series of novel hydrazones containing a 1,3-diketo moiety, namely 3-[(2E)-2-(4-hydroxybenzylidene)hydrazino]-3-oxo-N-phenylpropanamides (6a-j), were synthesized as precursors for biologically important β-lactam and thiazolidinone derivatives. The synthesis involved the condensation of 3-methoxy-4-hydroxybenzaldehyde or 3-methoxy-4-acetyloxybenzaldehyde with various substituted malonanilic acid hydrazides. The hydrazides (4a-e) were prepared by refluxing aniline with diethyl malonate, followed by treatment with hydrazine hydrate. The structures of the synthesized compounds were confirmed by elemental analysis and spectroscopic techniques, including IR, and 1H NMR spectrometry. The purity of the compounds was ascertained by thin-layer chromatography. The synthesized hydrazones (6a-j) were obtained in good yields (62-83%) and were soluble in dimethylformamide. The present study provides a foundation for further exploration of these 1,3-diketo amino compounds as promising scaffolds for developing novel heterocyclic compounds with diverse biological activities.
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